The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor that is abundantly expressed in liver. PPARα is activated by fatty acids and various …

Simple Summary In the context of liver disease, one of the more growing public health
problems is the transition from simple steatosis to non-alcoholic steatohepatitis. Profound …

Hepcidin is the principal iron regulatory hormone, controlling the systemic absorption and
remobilization of iron from intracellular stores. Recent in vivo studies have shown that …

Pattern of fat distribution is a major determinant for metabolic homeostasis. As a depot of
energy, the storage of triglycerides in adipose tissue contributes to the normal fat …

Liver fibrosis is the result of sustained chronic liver injury and inflammation leading to
hepatocyte cell death followed by the formation of fibrous scars, which is the hallmark of …

Interleukin-6 (IL-6) is implicated in multiple biological functions including immunity, neural
development, and haematopoiesis. Recently, mounting evidence indicates that IL-6 plays a …

Although parathyroid hormone (PTH) induces 25-hydroxyvitamin D 3 (25 (OH) D 3) 1α-
hydroxylase (1α (OH) ase) under hypocalcemic conditions, previous studies showed that …

The nutrient sensing nuclear receptor peroxisome proliferator-activated receptor-α (PPARα)
regulates the host response to short-term fasting by inducing hepatic transcriptional …

N-acetyl cysteine (NAC) is a versatile drug used in various conditions, but the limitations and
toxicities are not clear. The acute toxicity and toxicological mechanisms of an intraperitoneal …

Here we sought to evaluate the effect of palmitate on cytokine and PPAR activity/expression.
We investigated the effect of BSA conjugated palmitate and oleate on PPAR activity, PPAR-α …