Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Metabolic engineering encompasses several widely-used strategies, which currently hold a
high seat in the field of biotechnology when its potential is manifesting through a plethora of …

Tropane alkaloids (TAs) are widely distributed in the Solanaceae, while some important
medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted …

Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …

The marine environment is a huge reservoir of biodiversity and represents an excellent
source of chemical compounds, some of which have large economical values. In the urgent …

Microbial cell factories for terpenoid synthesis form a less expensive and more environment-
friendly approach than chemical synthesis and extraction, and are thus being regarded as …

Monoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized
metabolites mainly produced in Gentianales to cope with environmental challenges. Due to …

Benzylisoquinoline alkaloids (BIAs) are a diverse class of medicinal plant natural products.
Nearly 500 dimeric bisbenzylisoquinoline alkaloids (bisBIAs), produced by the coupling of …

Highlights•Systems metabolic engineering has enabled efficient production of natural
products.•Systems-level engineering of metabolism has increased pathway efficiencies.•Cell …

Secondary natural products (NPs) are a rich source for drug discovery. However, the low
abundance of NPs makes their extraction from nature inefficient, while chemical synthesis is …