CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules
W Feng, AM Newbigging, J Tao, Y Cao, H Peng… - Chemical …, 2021 - pubs.rsc.org
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-
associated (Cas) protein systems have transformed the field of genome editing and …
associated (Cas) protein systems have transformed the field of genome editing and …
Surface chemistry of gold nanoparticles for health-related applications
Functionalization of gold nanoparticles is crucial for the effective utilization of these materials
in health-related applications. Health-related applications of gold nanoparticles rely on the …
in health-related applications. Health-related applications of gold nanoparticles rely on the …
[HTML][HTML] Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA
ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic …
ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic …
Genome-editing technologies: concept, pros, and cons of various genome-editing techniques and bioethical concerns for clinical application
SH Khan - Molecular Therapy-Nucleic Acids, 2019 - cell.com
The traditional healthcare system is at the doorstep for entering into the arena of molecular
medicine. The enormous knowledge and ongoing research have now been able to …
medicine. The enormous knowledge and ongoing research have now been able to …
Liposome-based delivery of biological drugs
Biological drugs are attracting tremendous attention in disease treatment. However, their
application is significantly limited by their inherent properties, such as high hydrophilicity …
application is significantly limited by their inherent properties, such as high hydrophilicity …
Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing
R O'Flaherty, A Bergin, E Flampouri, LM Mota… - Biotechnology …, 2020 - Elsevier
The manufacturing of recombinant protein is traditionally undertaken in mammalian cell
culture. Today, speed, cost and safety are the primary considerations for process …
culture. Today, speed, cost and safety are the primary considerations for process …
Rational designs of in vivo CRISPR-Cas delivery systems
The CRISPR-Cas system initiated a revolution in genome editing when it was, for the first
time, demonstrated success in the mammalian cells. Today, scientists are able to readily edit …
time, demonstrated success in the mammalian cells. Today, scientists are able to readily edit …
Carrier strategies boost the application of CRISPR/Cas system in gene therapy
Z Xu, Q Wang, H Zhong, Y Jiang, X Shi, B Yuan… - …, 2022 - Wiley Online Library
Emerging clustered regularly interspaced short palindromic repeat/associated protein
(CRISPR/Cas) genome editing technology shows great potential in gene therapy. However …
(CRISPR/Cas) genome editing technology shows great potential in gene therapy. However …
All‐in‐one dendrimer‐based lipid nanoparticles enable precise HDR‐mediated gene editing in vivo
Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‐associated
(Cas) protein gene editing is poised to transform the treatment of genetic diseases …
(Cas) protein gene editing is poised to transform the treatment of genetic diseases …
Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing
CRISPR/Cas9-based genome editing has quickly emerged as a powerful breakthrough
technology for use in diverse settings across biomedical research and therapeutic …
technology for use in diverse settings across biomedical research and therapeutic …