[HTML][HTML] Solving neurodegeneration: common mechanisms and strategies for new treatments
LK Wareham, SA Liddelow, S Temple… - Molecular …, 2022 - Springer
Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic
targets based on neuronal protection, repair, or regeneration, independent of etiology or site …
targets based on neuronal protection, repair, or regeneration, independent of etiology or site …
The chaperone Clusterin in neurodegeneration− friend or foe?
Fibrillar protein aggregates are the pathological hallmark of a group of age‐dependent
neurodegenerative conditions, including Alzheimer's and Parkinson's disease. Aggregates …
neurodegenerative conditions, including Alzheimer's and Parkinson's disease. Aggregates …
Nutrition in Alzheimer's disease: A review of an underappreciated pathophysiological mechanism
J Jiang, H Shi, S Jiang, A Wang, X Zou, Y Wang… - Science China Life …, 2023 - Springer
Alzheimer's disease (AD) is the leading cause of dementia in older individuals and is an
escalating challenge to global public health. Pharmacy therapy of AD is one of the well …
escalating challenge to global public health. Pharmacy therapy of AD is one of the well …
[HTML][HTML] Advanced glycation end-products and its soluble receptor are not independent predictors of incident dysglycaemia or metabolic syndrome in women with …
YW Tong, JKY Ko, KSL Lam, S Tam, VCY Lee… - Reproductive Biology …, 2023 - Springer
Background To evaluate the association of serum advanced glycation end-products (AGEs)
and its soluble receptor of AGE (sRAGE) levels with dysglycaemia and metabolic syndrome …
and its soluble receptor of AGE (sRAGE) levels with dysglycaemia and metabolic syndrome …
[HTML][HTML] Comorbidity genes of Alzheimer's disease and type 2 diabetes associated with memory and cognitive function
SB Cho - International Journal of Molecular Sciences, 2024 - mdpi.com
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are comorbidities that result
from the sharing of common genes. The molecular background of comorbidities can provide …
from the sharing of common genes. The molecular background of comorbidities can provide …
Examining the effects of the CLU and APOE polymorphisms' combination on coronary artery disease complexed with type 2 diabetes mellitus
AS Ozuynuk, AF Erkan, N Dogan, B Ekici… - Journal of Diabetes and …, 2022 - Elsevier
Aims Coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) are important and
increasing public health problems. This study aimed to identify the impact of APOE and CLU …
increasing public health problems. This study aimed to identify the impact of APOE and CLU …
Wide-spread enhancer effect of SNP rs2279590 on regulating epoxide hydrolase-2 and protein tyrosine kinase 2-beta gene expression
B Padhy, RS Kapuganti, B Hayat, PP Mohanty… - Gene, 2023 - Elsevier
Polymorphisms in the PTK2B-CLU locus have been associated with various
neurodegenerative disorders including pseudoexfoliation glaucoma, Alzheimer's and …
neurodegenerative disorders including pseudoexfoliation glaucoma, Alzheimer's and …
Genetic biomarkers of cognitive impairment and dementia of potential interest in CKD patients
C Zoccali, G Capasso - Journal of Nephrology, 2024 - Springer
This review discusses genetic variants associated with cognitive dysfunction in chronic
kidney disease (CKD) patients, emphasising the limited research in this area. Four studies …
kidney disease (CKD) patients, emphasising the limited research in this area. Four studies …
[HTML][HTML] Deregulated clusterin as a marker of bone fragility: New insights into the pathophysiology of osteoporosis
VV Visconti, C Greggi, I Cariati, B Gasperini… - Genes, 2022 - mdpi.com
Clusterin (CLU) is a secreted heterodimeric glycoprotein expressed in all organism fluids as
well as in the intracellular matrix that plays key roles in several pathological processes. Its …
well as in the intracellular matrix that plays key roles in several pathological processes. Its …
Link of BIN1, CLU, and IDE Gene Polymorphisms with the Susceptibility of Alzheimer's Disease: Evidence from a Meta-analysis
A Aziz, G Md Ashraf… - Current Alzheimer …, 2022 - ingentaconnect.com
Background: Alzheimer's disease (AD) is the most common form of neurodegenerative
disorder. The association of BIN1, CLU, and IDE genetic polymorphisms with AD risk have …
disorder. The association of BIN1, CLU, and IDE genetic polymorphisms with AD risk have …