Laminins (LM) are extracellular matrix molecules that contribute to and are required for the
formation of basement membranes. They participate in the modulation of epithelial …

Background Hedgehog signaling plays an important role in embryonic development,
organogenesis and cancer. In the adult liver, Hedgehog signaling in non-parenchymal cells …

Articular cartilage damage with subsequent impairment of joint function is a common feature
of articular diseases, in particular, rheumatoid arthritis and osteoarthritis. While articular …

Human mesenchymal stem cells (hMSC) have the ability to differentiate into osteoblasts,
adipocytes and chondrocytes. We have previously shown that hMSC were endowed with a …

Chronic inflammation has a certain impact on the carcinogenesis of the digestive organs.
The characteristic tissue structure of pancreatic cancer, desmoplasia, results from …

Summary Acyl-CoA thioesterase 1 (ACOT1) is an important isoform of the ACOT family that
catalyzes the reaction of fatty acyl–CoAs to CoA-SH and free fatty acids. Recent studies of …

The gastric epithelium is continuously regenerated by gastric stem cells, which give rise to
various kinds of daughter cells, including parietal cells, chief cells, surface mucous cells …

Radiation-induced fibrosis constitutes a major problem that is commonly observed in the
patients undergoing radiotherapy; therefore, understanding its pathophysiological …

The sonic hedgehog (SHH) pathway is activated in several types of malignancy and plays
an important role in tumor cell proliferation and tumorigenesis. SHH binding to a 12-pass …

The gonad appears in the early embryo after several events: cells at the lateral plate
mesoderm (LPM) undergo ingression, begin gonadal differentiation and then retain …