Macrophages are a protective replicative niche for Mycobacterium tuberculosis (Mtb) but can
kill the infecting bacterium when appropriately activated. To identify mechanisms of …

Metabolic flux is the final output of cellular regulation and has been extensively studied for
carbon but much less is known about nitrogen, which is another important building block for …

Tuberculosis (TB) is an ancient and deadly disease characterized by complex host-
pathogen dynamics playing out over multiple time and length scales and physiological …

Metabolic flux analysis (MFA) is an increasingly important tool to study metabolism
quantitatively. Unlike the concentrations of metabolites, the fluxes, which are the rates at …

Mycobacterium tuberculosis is the cause of tuberculosis (TB), a disease which continues to
overwhelm health systems in endemic regions despite the existence of effective combination …

The mechanisms whereby Mycobacterium tuberculosis (Mtb) rewires the host metabolism in
vivo are surprisingly unexplored. Here, we used three high-resolution mass spectrometry …

Metabolic adaptation of Mycobacterium tuberculosis (M. tuberculosis) to microbicidal
intracellular environment of host macrophages is fundamental to its pathogenicity. However …

Mycobacterium tuberculosis is an ancient master of the art of causing human disease. One
important weapon within its fully loaded arsenal is the type VII secretion system. M …

The pathogenic success of Mycobacterium tuberculosis (Mtb) is tightly linked to its ability to
recalibrate host metabolic processes in infected host macrophages. Since changes in …

Human tuberculosis (TB) is amongst the oldest and deadliest human bacterial diseases that
pose major health, social and economic burden at a global level. Current regimens for TB …