Background: Salivary exosomal miRNAs as biomarkers facilitate repeated sampling, real-
time disease monitoring and assessment of therapeutic response. This study identifies a …

Abstract Background SARS-CoV-2, the pathogen of COVID-19, is a worldwide threat to
human health and causes a long-term burden on the cardiovascular system. Individuals with …

INTRODUCTION Our previous antibody‐based cerebrospinal fluid (CSF) proteomics study
showed that Thimet oligopeptidase (THOP1), an amyloid beta (Aβ) neuropeptidase, was …

Phosphinic peptides constitute an important class of bioactive compounds that have found a
wide range of applications in the field of biology and pharmacology of Zn-metalloproteases …

Neurolysin oligopeptidase (EC 3.4. 24.16; Nln), a member of the zinc metallopeptidase M3
family, was first identified in rat brain synaptic membranes hydrolyzing neurotensin at the …

Non-alcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of conditions from
simple steatosis (non-alcoholic fatty liver (NAFL)) to non-alcoholic steatohepatitis (NASH) …

Peptidases generate bioactive peptides that can regulate cell signaling and mediate
intercellular communication. While the processing of peptide precursors is initiated …

Intracranial saccular aneurysms (ISA) represent 90%–95% of all intracranial aneurysm
cases, characterizing abnormal pockets at arterial branch points. Ruptures lead to …

Clinical use of doxorubicin (Dox) is limited by cumulative myelo-and cardiotoxicity. This
research focuses on the detailed characterization of PhAc-ALGP-Dox, a targeted …

Intracellular peptides were shown to derive from proteasomal degradation of proteins from
mammalian and yeast cells, being suggested to play distinctive roles both inside and …