Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons
in the central nervous system. APOE-dependent alterations of the endocytic pathway can …

Background—Patients with pulmonary arterial hypertension (PAH) have reduced expression
of apolipoprotein E (apoE) and peroxisome proliferator–activated receptor-γ in lung tissues …

Pulmonary hypertension (PH) is a disorder that develops as a result of remodeling of the
pulmonary vasculature and is characterized by narrowing/obliteration of small pulmonary …

Atherosclerosis is a chronic inflammatory disease that is characterized by the development
of fibrotic plaques in the arterial wall. The disease exhibits a complex aetiology and its …

Plasma levels of high-density lipoproteins (HDL) and apolipoprotein AI (apoA-I) are
inversely correlated with the risk of cardiovascular disease. One major atheroprotective …

Peripheral blood monocytes migrate to and accumulate in hypoxic areas of inflammatory
and tumor lesions. To characterize the molecular bases underlying monocyte functions …

Atherosclerosis, the underlying cause of myocardial infarction and thrombotic
cerebrovascular events, is responsible for the majority of deaths in westernized societies …

Sex differences in coronary artery disease (CAD) presentation, risk factors and prognosis
have been widely studied. Similarly, studies on atherosclerosis have shown prominent sex …

Hypertension and atherosclerosis, the predecessors of stroke and myocardial infarction, are
chronic vascular inflammatory reactions. Tumor necrosis factor alpha (TNFα), the “master” …

Objective—Recent studies indicate that the ATP-binding cassette transporter ABCG1 can
promote cholesterol efflux from macrophages to high-density lipoprotein. This study was …