Establishment of a novel mouse model for atherosclerotic vulnerable plaque

X Wang, Y Fu, Z Xie, M Cao, W Qu, X Xi… - Frontiers in …, 2021 - frontiersin.org
Background and Aims: Acute coronary syndrome (ACS) is a group of clinical syndromes
characterized by rupture or erosion of atherosclerotic unstable plaques. Effective …

Coherent somatic mutation in autoimmune disease

KA Ross - PloS one, 2014 - journals.plos.org
Background Many aspects of autoimmune disease are not well understood, including the
specificities of autoimmune targets, and patterns of co-morbidity and cross-heritability across …

Cholesterol transport by the placenta: placental liver X receptor activity as a modulator of fetal cholesterol metabolism?

T Plösch, EME Van Straten, F Kuipers - Placenta, 2007 - Elsevier
Cholesterol is an important sterol in mammals. Defects in cholesterol synthesis or
intracellular routing have devastating consequences already in utero: the Smith–Lemli …

Influence of apolipoprotein E gene polymorphism on development of type 2 diabetes mellitus in Chinese Han population: a meta-analysis of 29 studies

YW Yin, L Qiao, QQ Sun, AM Hu, HL Liu, Q Wang… - Metabolism, 2014 - Elsevier
Objectives Published data regarding the association between apolipoprotein E (ApoE) gene
polymorphism and type 2 diabetes mellitus (T2DM) risk in Chinese Han population were …

Haptoglobin binds apolipoprotein E and influences cholesterol esterification in the cerebrospinal fluid

A Salvatore, L Cigliano, A Carlucci… - Journal of …, 2009 - Wiley Online Library
Haptoglobin (Hpt) binds the apolipoprotein (Apo) A–I domain, which is involved in
stimulating the enzyme lecithin‐cholesterol acyltransferase (LCAT) for cholesterol …

ApoE polymorphisms and the risk of different subtypes of stroke in the Chinese population: a comprehensive meta-analysis

C Chen, Z Hu - Cerebrovascular Diseases, 2016 - karger.com
Abstract Background and Purpose: Numerous studies have evaluated the association
between apolipoprotein E (ApoE) gene polymorphisms and the risk of different subtypes of …

Haptoglobin binds the antiatherogenic protein apolipoprotein E–impairment of apolipoprotein E stimulation of both lecithin: cholesterol acyltransferase activity and …

L Cigliano, CR Pugliese, MS Spagnuolo… - The FEBS …, 2009 - Wiley Online Library
Haptoglobin (Hpt) binds apolipoprotein A‐I (ApoA‐I), and impairs its stimulation of lecithin:
cholesterol acyltransferase (LCAT). LCAT plays a major role in reverse cholesterol transport …

ApoE ε2/ε3/ε4 polymorphism, ApoC-III/ApoE ratio and metabolic syndrome

O Olivieri, N Martinelli, A Bassi, E Trabetti… - Clinical and …, 2007 - Springer
Triglyceride-rich lipoproteins contain both apolipoproteins E (ApoE) and C-III (ApoC-III),
which show opposite functional properties. The relationships between the ApoE (ε2/ε3/ε4) …

Application of proteomics technology in adipocyte biology

J Renes, E Mariman - Molecular BioSystems, 2013 - pubs.rsc.org
Obesity and its associated complications have reached epidemic proportions in Western-
type societies. Concomitantly, the obesity incidence in developing countries is increasing …

A mouse model of hypercholesterolemia-induced erectile dysfunction

D Xie, SI Odronic, F Wu, AM Pippen… - The Journal of …, 2007 - academic.oup.com
Introduction Hypercholesterolemia is one of the most important risk factors for the
development of erectile dysfunction (ED) in men. Aim We employed an established mouse …