Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is
important for very low-density lipoprotein (VLDL) production and thus energy distribution to …

Low-grade inflammation is a common feature in subjects with type 2 diabetes (T2D). Heart
disease, the metabolic syndrome and T2D all have in common the increased concentration …

Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently
the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the …

Objective The gut microbiota has been proposed as an interesting therapeutic target for
metabolic disorders. Inulin as a prebiotic has been shown to lessen obesity and related …

Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …

Metformin is an oral antihyperglycemic drug widely used to treat type 2 diabetes mellitus
(T2DM), acting via indirect activation of 5′ Adenosine monophosphate-activated Protein …

In humans, uric acid is the final oxidation product of purine catabolism. The serum uric acid
level is based on the balance between the absorption, production and excretion of purine …

Background—Pulmonary hypertension associated with heart failure with preserved ejection
fraction (PH-HFpEF) is an increasingly recognized clinical complication of metabolic …

Blueberries or bilberries contain large amounts of anthocyanins, making them one of the
richest sources of dietary anthocyanin. These berries are widely consumed as fresh and …

AMPK (AMP-activated protein kinase) is a phylogenetically conserved fuel-sensing enzyme
that is present in all mammalian cells. During exercise, it is activated in skeletal muscle in …