The aim of this tutorial review is to introduce the reader to the concept, synthesis and
application of natural product-inspired compound collections as an important field in …

Finding small molecules that modulate protein function is of primary importance in drug
development and in the emerging field of chemical genomics. To facilitate the identification …

The total synthesis of largazole and four analogues is reported. All analogues were
nanomolar HDAC inhibitors. The antiproliferative activity is driven by lipophilicity and cell …

Approximately, 63% of marketed drugs derive from natural products or their semi synthetic
derivatives. Compounds from living organisms often exert a biological activity, triggering …

A broad set of potential bioactive conjugate compounds has been semi-synthesized through
solution-and solid-phase organic procedures, coupling two natural pentacyclic triterpene …

To evade the problem of multidrug resistance, hybridization of natural products in dimers is
considered as an effective method. After the successful synthesis of three artesunic acid …

A concept, natural products derivatization method (NPDM), was introduced to assess the
influence of natural products on the discovery of targeted anticancer agents. Subsequently …

Gliomas are primary brain tumors with still poor prognosis for the patients despite a
combination of cytoreduction via surgery followed by a radio-chemotherapy. One strategy to …

From ancient times, herbal medicines are in use to cure the diseases due to their potential
and less side effects. But difficulties in identification, processing, standardizing, extracting of …

Scintillation proximity assay (SPA), characterized by its speed, sensitivity, reliability, and the
fact that no separation step is required, has become an important technique in high …