RNA-based gene therapy requires therapeutic RNA to function inside target cells without
eliciting unwanted immune responses. RNA can be ferried into cells using non-viral drug …

Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has
resulted in the emergence of epitranscriptomics as a research field. The most abundant …

The current COVID-19 pandemic is a massive source of global disruption, having led so far
to two hundred million COVID-19 cases and more than four million deaths worldwide. It was …

Gene therapy is on its way to revolutionize the treatment of both inherited and acquired
diseases, by transferring nucleic acids to correct a disease-causing gene in the target cells …

Oligonucleotide therapeutics are attracting attention as a new treatment modality for a range
of diseases that have been difficult to target using conventional approaches. Technical …

Both personalized medicine and nanomedicine are new to medical practice. Nanomedicine
is an application of the advances of nanotechnology in medicine and is being integrated into …

O-methylation (Nm) is a prominent RNA modification well known in noncoding RNAs and
more recently also found at many mRNA internal sites. However, their function and base …

Peptide nucleic acids (PNAs) are an important class of DNA/RNA mimics that can hybridize
complementary chains of nucleic acids with high affinity and specificity. Because of this …

Hemophilia is a monogenic mutational disease affecting coagulation factor VIII or factor IX
genes. The palliative treatment of choice is based on the use of safe and effective …

In this study we investigated the separation of a 25 mer fully phosphorothioated
oligonucleotide from its truncated n-1 (24 mer) species and selected phosphodiester 25 mer …