Hereditary spastic paraplegias (HSPs) comprise a family of degenerative diseases mostly
hitting descending axons of corticospinal neurons. Depending on the gene and mutation …

Coat protein complex II (COPII) plays an integral role in the packaging of secretory cargoes
within membrane-enclosed transport carriers that leave the endoplasmic reticulum (ER) from …

The mechanism that maintains ER-to-Golgi vesicles formation and transport is complicated.
As one of the adapters, Ninein-like protein (Nlp) participated in assembly and transporting of …

Immune checkpoint inhibition targeting the PD-1/PD-L1 pathway has become a powerful
clinical strategy for treating cancer, but its efficacy is complicated by various resistance …

Background Mutations in the tropomyosin receptor kinase fused (TFG) gene are associated
with various neurological disorders, including autosomal recessive hereditary spastic …

Objective TFG mutations have previously been implicated in autosomal recessive hereditary
spastic paraplegia (HSP), also known as SPG57. This study aimed to investigate the clinical …

Hereditary spastic paraplegia is a genetically heterogeneous neurodegenerative disorder
characterised primarily by muscle stiffness in the lower limbs. Neurodegenerative disorders …

The parasitic protozoa Toxoplasma gondii chronically infects the central nervous system of
an estimated one-third of the human population. Infection is generally subclinical, but …

Co-assembly of the multilayered coat protein complex II (COPII) with the Sari GTPase at
subdomains of the endoplasmic reticulum (ER) enables secretory cargoes to be …

Proper cargo trafficking is critical for secretory cells to maintain health and biological
functions, where mutations along the secretory pathway have demonstrated incompatibility …