Non-coding RNAs and potential therapeutic targeting in cancer

S Toden, TJ Zumwalt, A Goel - … et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …

[HTML][HTML] The emerging role of the piRNA/piwi complex in cancer

Y Liu, M Dou, X Song, Y Dong, S Liu, H Liu, J Tao, W Li… - Molecular cancer, 2019 - Springer
Piwi interacting RNAs (piRNAs) constitute novel small non-coding RNA molecules of
approximately 24–31 nucleotides in length that often bind to members of the piwi protein …

Protein arginine methyltransferases and cancer

Y Yang, MT Bedford - Nature Reviews Cancer, 2013 - nature.com
There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation …

Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer

Y Pekarsky, V Balatti, A Palamarchuk… - Proceedings of the …, 2016 - National Acad Sciences
Chronic lymphocytic leukemia (CLL) is the most common human leukemia, and transgenic
mouse studies indicate that activation of the T-cell leukemia/lymphoma 1 (TCL1) oncogene …

[HTML][HTML] The regulatory function of piRNA/PIWI complex in cancer and other human diseases: The role of DNA methylation

DD Jia, H Jiang, YF Zhang, Y Zhang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Piwi-interacting RNAs (piRNAs) are a class of short chain noncoding RNAs that are
constituted by 26-30 nucleotides (nt) and can couple with PIWI protein family. piRNAs were …

[HTML][HTML] Non-coding RNAs: multi-tasking molecules in the cell

AQ Gomes, S Nolasco, H Soares - International journal of molecular …, 2013 - mdpi.com
In the last years it has become increasingly clear that the mammalian transcriptome is highly
complex and includes a large number of small non-coding RNAs (sncRNAs) and long …

[HTML][HTML] PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA

L Tan, D Mai, B Zhang, X Jiang, J Zhang, R Bai, Y Ye… - Molecular cancer, 2019 - Springer
Background Breast cancer is one of the most common malignancies and the major cause of
cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) …

[HTML][HTML] Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal …

W Weng, N Liu, Y Toiyama, M Kusunoki, T Nagasaka… - Molecular cancer, 2018 - Springer
Background Emerging evidence suggests that PIWI-interacting RNAs (piRNAs) may be
important epigenetic regulators of gene expression in human cancers; however, their …

piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells

J Cheng, H Deng, B Xiao, H Zhou, F Zhou, Z Shen… - Cancer letters, 2012 - Elsevier
Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with
chromatin organization, messenger RNA stability and genome structure. However, the roles …

[HTML][HTML] PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma

D Mai, P Ding, L Tan, J Zhang, Z Pan, R Bai, C Li… - Theranostics, 2018 - ncbi.nlm.nih.gov
Abstract Although PIWI-interacting RNAs (piRNAs) have recently been linked to human
diseases, their roles and functions in malignancies remain unclear. This study aimed to …