Pre-eclampsia

E Dimitriadis, DL Rolnik, W Zhou… - Nature reviews Disease …, 2023 - nature.com
Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …

Clinical consequences of defective decidualization

C Ticconi, N Di Simone, L Campagnolo, A Fazleabas - Tissue and Cell, 2021 - Elsevier
Decidualization is characterized by a series of genetic, metabolic, morphological,
biochemical, vascular and immune changes occurring in the endometrial stroma in …

Etiological value of sterile inflammation in preeclampsia: is it a non-infectious pregnancy complication?

S Banerjee, Z Huang, Z Wang, A Nakashima… - Frontiers in Cellular …, 2021 - frontiersin.org
Understanding of sterile inflammation and its associated biological triggers and diseases is
still at the elementary stage. This becomes more warranted in cases where infections are not …

The placental NLRP3 inflammasome and its downstream targets, caspase-1 and interleukin-6, are increased in human fetal growth restriction: implications for …

I Alfian, A Chakraborty, HEJ Yong, S Saini, RWK Lau… - Cells, 2022 - mdpi.com
Fetal growth restriction (FGR) is commonly associated with placental insufficiency and
inflammation. Nonetheless, the role played by inflammasomes in the pathogenesis of FGR is …

Metformin in gestational diabetes mellitus: to use or not to use, that is the question

V Tocci, M Mirabelli, A Salatino, L Sicilia, S Giuliano… - Pharmaceuticals, 2023 - mdpi.com
In recent years, there has been a dramatic increase in the number of pregnancies
complicated by gestational diabetes mellitus (GDM). GDM occurs when maternal insulin …

[HTML][HTML] A meta-analysis for the risk and prevalence of preeclampsia among pregnant women with COVID-19

M Karimi-Zarchi, DA Schwartz, R Bahrami… - Turkish Journal of …, 2021 - ncbi.nlm.nih.gov
Preeclampsia and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection
are both life-threatening disorders when they occur during pregnancy. They are similarly …

Sodium butyrate alleviates pre‐eclampsia in pregnant rats by improving the gut microbiota and short‐chain fatty acid metabolites production

W Yong, Y Zhao, X Jiang, P Li - Journal of Applied Microbiology, 2022 - academic.oup.com
Aims Pre‐eclampsia (PE) affects pregnant patients worldwide, but there is no effective
treatment for this condition. We aimed to explore the effect of sodium butyrate (NaB) on PE …

[HTML][HTML] SARS-CoV-2 infection and oxidative stress in early-onset preeclampsia

R Marín, FH Pujol, D Rojas, L Sobrevia - Biochimica et Biophysica Acta …, 2022 - Elsevier
SARS-CoV-2 causes coronavirus disease 2019 (COVID-19) also in pregnant women.
Infection in pregnancy leads to maternal and placental functional alterations. Pregnant …

Primary cilia in trophoblastic cells: potential involvement in preeclampsia

A Ritter, S Roth, NN Kreis, A Friemel, SC Hoock… - …, 2020 - Am Heart Assoc
The pathogenesis of preeclampsia, a pregnancy-related disease, is not completely
understood. The primary cilium transduces a diverse array of signaling pathways important …

Pathophysiological effects of contemporary lifestyle on evolutionary-conserved survival mechanisms in polycystic ovary syndrome

J Parker - Life, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is increasingly being characterized as an evolutionary
mismatch disorder that presents with a complex mixture of metabolic and endocrine …