Despite structural differences between the right-handed conformations of A-RNA and B-
DNA, both nucleic acids adopt very similar, left-handed Z-conformations. In contrast to their …

Z-RNA is a higher-energy, left-handed conformation of RNA, whose function has remained
elusive. A growing body of work alludes to regulatory roles for Z-RNA in the immune …

Given the many roles proposed for Mg2+ in nucleic acids, it is essential to accurately
determine their binding modes. Here, we surveyed the PDB to classify Mg2+ inner-sphere …

The left-handed Z-conformation of nucleic acids can be adopted by both DNA and RNA
when bound by Zα domains found within a variety of innate immune response proteins. Zα …

The glycosyl torsion (χ) in nucleic acids has long been recognized to be a major determinant
of their conformational properties. χ torsional energetics were systematically mapped in …

Hydrogen bond (H-bond) formation in water has been a challenging task because water
molecules are constant competitors. In biological systems, however, stable H-bonds are …

Studies on hydration are important for better understanding of structure and function of
nucleic acids. We compared the hydration of self‐complementary DNA, RNA and 2′‐O …

Z-DNA and Z-RNA are functionally important left-handed structures of nucleic acids, which
play a significant role in several molecular and biological processes including DNA …

Since the work of Alexander Rich, who solved the first Z-DNA crystal structure, we have
known that d (CpG) steps can adopt a particular structure that leads to forming left-handed …

The Z-DNA conformation preferentially occurs at alternating purine-pyrimidine repeats, and
is specifically recognized by Zα domains identified in several Z-DNA-binding proteins. The …