Systematic reviews of diagnostic test accuracy (DTA) studies are fundamental to the
decision making process in evidence based medicine. Although such studies are regarded …

The management of viral hepatitis in the setting of pregnancy requires special consideration.
There are five liver-specific viruses (hepatitis A, B, C, D, E), each with unique epidemiology …

Key points What is already known about this topic? In 2015, the International Society for
Prenatal Diagnosis (ISPD) published its first position statement on the use of non‐invasive …

Approximately 3% to 5% of pregnancies are complicated by birth defects or genetic
disorders. 1 Chromosomal abnormalities are present in approximately 1 in 150 live births, 2 …

Differences/disorders of sex development (DSD) are a heterogeneous group of congenital
conditions that result in discordance between an individual's sex chromosomes, gonads …

Background Non-invasive prenatal testing (NIPT) can be used to accurately detect fetal
chromosomal anomalies early in pregnancy by assessing cell-free fetal DNA present in …

Introduction The aim of this study was to review the performance of non‐invasive prenatal
testing (NIPT) for detection of trisomy 21, 18 and 13 (T21, T18 and T13) in a general …

Background Common fetal aneuploidies include Down syndrome (trisomy 21 or T21),
Edward syndrome (trisomy 18 or T18), Patau syndrome (trisomy 13 or T13), Turner …

Screening for chromosomal disorders, especially for trisomy 21, has undergone a number of
changes in the last 50 years. Today, cell-free DNA analysis (cfDNA) is the gold standard in …

Objective In this study, we expanded conventional cell‐free fetal DNA (cfDNA)‐based non‐
invasive prenatal testing (NIPT) to cover the entire genome. We aimed to compare the …