The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …

▪ Abstract Interleukin-12 (IL-12) is a heterodimeric cytokine that plays a central role in
promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated immunity. Its …

IL-23 is a heterodimeric cytokine composed of the IL-12p40 “soluble receptor” subunit and a
novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit …

Publisher Summary Although interleukin-12 (IL-12) has been discovered only relatively
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …

WSX-1 is a class I cytokine receptor with homology to the IL-12 receptors. The physiological
role of WSX-1, which is expressed mainly in T cells, was investigated in gene-targeted WSX …

We analyzed the molecular mechanisms by which IL-12 and IL-18 induce transcriptional
activity of the IFN-γ promoter in primary human CD4+ T cells. In transfection experiments, we …

Brucella spp. are intracellular gram-negative bacteria that include a number of virulent
species that cause chronic infections in a variety of mammalian hosts. Human infections are …

Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a
wide range of infectious diseases. In several experimental models of bacterial, parasitic …

Regulation of the factors governing IL-12R expression and IL-12 responsiveness has been
shown to be important in the generation and stability of Th1-and Th2-type responses. In this …

The role of TGF‐β1 in the regulation of T cell responses has been perplexing, possibly
because it is dependent on the type of T cell being regulated and its cytokine …