Wnt5a/Ca2+ signaling regulates silica-induced ferroptosis in mouse macrophages by altering ER stress-mediated redox balance

J Ma, J Wang, C Ma, Q Cai, S Wu, W Hu, J Yang, J Xue… - Toxicology, 2023 - Elsevier
Silicosis is a chronic pulmonary disease characterized by diffuse fibrosis of lung caused by
the deposition of silica dust (SiO 2). The inhaled silica-induced oxidative stress, ROS …

Bmi1 signaling maintains the plasticity of airway epithelial progenitors in response to persistent silica exposures

J Yang, S Wu, W Hu, D Yang, J Ma, Q Cai, J Xue… - Toxicology, 2022 - Elsevier
Silicosis is caused by the continuous inhalation of environmental silica dust. The repetitive
exposure of silica induces airway epithelial cell injury, leads proliferative exhaustion of …

Serum metabolic profiling of coal worker's pneumoconiosis using untargeted lipidomics

F Peng, J Dai, Q Qian, X Cao, L Wang, M Zhu… - … Science and Pollution …, 2022 - Springer
In this work, untargeted lipidomics was employed to analyze the effects of coal dust
exposure on serum metabolite profiles. Furthermore, the potential of differential metabolites …

Transcriptomic and proteomic changes driving pulmonary fibrosis resolution in young and old mice

J Weckerle, CH Mayr, K Fundel-Clemens… - American Journal of …, 2023 - atsjournals.org
Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic
pulmonary fibrosis. Yet in this model, it spontaneously resolves over time. We studied …

[HTML][HTML] Reserve of Wnt/β-catenin signaling alleviates Mycoplasma pneumoniae P1-C-induced inflammation in airway epithelial cells and lungs of mice

J Shi, C Ma, X Hao, H Luo, M Li - Molecular Immunology, 2023 - Elsevier
Mycoplasma pneumoniae (M. pneumoniae) is the most common pathogen of respiratory
tract infections in both children and adults. M. pneumoniae P1 adhesin plays an important …

Human embryonic stem cell‐derived mesenchymal stem cell secretome reverts silica‐induced airway epithelial cell injury by regulating Bmi1 signaling

J Yang, J Xue, W Hu, L Zhang, R Xu… - Environmental …, 2023 - Wiley Online Library
Silicosis is an irreversible chronic pulmonary disease caused by long‐term inhalation and
deposition of silica particles, which is currently incurable. The exhaustion of airway epithelial …