The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways
is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we …

Gallium-based liquid metal (LM) exhibits exceptional properties such as high conductivity
and biocompatibility, rendering it highly valuable for the development of conformal …

Alternative transcription start site usage (ATSS) is a widespread regulatory strategy that
enables genes to choose between multiple genomic loci for initiating transcription. This …

Two recent studies, coauthored by us, reported age-associated increase in transcriptional
stress due to elevated stalling of RNA polymerases and accelerated transcription …

We are facing a growing aging population, along with increasing pressure on health
systems, caused by the impact of chronic co‐morbidities (ie cancer, cardiovascular and …

The senescence of fruit is a complex physiological process, with various cell types within the
pericarp, making it highly challenging to elucidate their individual roles in fruit senescence …

Dormancy is a key feature of stem cell function in adult tissues as well as in embryonic cells
in the context of diapause. The establishment of dormancy is an active process that involves …

Organs and tissues age at different rates within a single individual. Such asynchrony in
aging has been widely observed at multiple levels, from functional hallmarks, such as …