Acute kidney injury (AKI) is a global public health concern associated with high morbidity,
mortality, and healthcare costs. Other than dialysis, no therapeutic interventions reliably …

Acute kidney injury is an increasingly common complication of hospital admission and is
associated with high levels of morbidity and mortality. A hypotensive, septic, or toxic insult …

Cellular senescence, a persistent state of cell cycle arrest, accumulates in aged organisms,
contributes to tissue dysfunction, and drives age-related phenotypes. The clearance of …

Kidneys have the capacity for intrinsic repair, preserving kidney architecture with return to a
basal state after tubular injury. When injury is overwhelming or repetitive, however, that …

Kidney cells and tissues derived from human pluripotent stem cells (hPSCs) may enable
organ regeneration, disease modeling and drug screening. We report an efficient …

Regulated necrosis has been reported to exert an important role in the pathogenesis of
various diseases, including renal ischemia-reperfusion (I/R) injury. Damage to renal tubular …

There is an alarming global increase in the incidence of end-stage kidney disease, for which
early biomarkers and effective treatment options are lacking. Largely based on the histology …

Recent clinical studies indicate a strong link between AKI and progression of CKD. The
increasing prevalence of AKI must compel the nephrology community to consider the long …

Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here,
we review the major components of this dynamic process, which involves hemodynamic …

Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …