Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here,
we review the major components of this dynamic process, which involves hemodynamic …

A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal
muscle mass and strength,. Although the etiology of sarcopenia is unknown, the correlation …

Acute kidney injury (AKI) is a common clinical state resulting from pathogenic conditions
such as ischemic and toxic insults. The pathophysiology of AKI shares common pathogenic …

Microvesicles (MVs) are circular fragments of membrane released from the endosomal
compartment as exosomes or shed from the surface membranes of most cell types. An …

Though an acute kidney injury (AKI) episode is associated with an increased risk of chronic
kidney disease (CKD), the mechanisms determining the transition from acute to irreversible …

Fibrosis is responsible for chronic progressive kidney failure, which is present in a large
number of adults in the developed world. It is increasingly appreciated that acute kidney …

Whether kidney proximal tubule harbors a scattered population of epithelial stem cells is a
major unsolved question. Lineage-tracing studies, histologic characterization, and ex vivo …

Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event leading
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …

Understanding the origin of myofibroblasts in kidney is of great interest because these cells
are responsible for scar formation in fibrotic kidney disease. Recent studies suggest …

Background. Several studies demonstrated that mesenchymal stem cells (MSCs) reverse
acute kidney injury (AKI) by a paracrine mechanism rather than by MSC transdifferentiation …