Phenotypic changes induced by extracellular vesicles have been implicated in
mesenchymal stromal cell–promoted recovery of AKI. MicroRNAs are potential candidates …

Recently we have established that the kidney tubular epithelium is repaired by surviving
epithelial cells. It is not known, however, whether a population of intratubular adult …

Macrophages are required for tissue homeostasis through their role in regulation of the
immune response and the resolution of injury. Here we show, using the kidney as a model …

Pericytes are the major source of scar-producing myofibroblasts following kidney injury;
however, the mechanisms of this transition are unclear. To clarify this, we examined …

The proximal tubule has a remarkable capacity for repair after acute injury, but the cellular
lineage and molecular mechanisms underlying this repair response are incompletely …

Depletion of podocytes, common to glomerular diseases in general, plays a role in the
pathogenesis of glomerulosclerosis. Whether podocyte injury in adulthood can be repaired …

Renal tubule epithelia represent the primary site of damage in acute kidney injury (AKI), a
process initiated and propagated by the infiltration of macrophages. Here we investigated …

Renal ischemia reperfusion injury (IRI) is associated with significant morbidity and mortality.
Given the importance of microRNAs (miRNAs) in regulating gene expression, we examined …

In chronic kidney disease, fibroblast dysfunction causes renal fibrosis and renal anemia.
Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is …

Recent clinical and animal studies have shown that acute kidney injury (AKI), even if
followed by complete recovery of renal function, can eventually result in chronic kidney …