Increasing evidence has demonstrated the bidirectional link between acute kidney injury
(AKI) and chronic kidney disease (CKD) such that, in the clinical setting, the new concept of …

Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the
primary underlying insult. It is a complex phenomenon governed by the interplay between …

Chronic kidney disease is a leading cause of death in the United States. Tubulointerstitial
fibrosis (TIF) is considered the final common pathway leading to end-stage renal disease …

The mammalian kidney is a complex organ consisting of multiple cell types. We previously
showed that the Six2-expressing cap mesenchyme is a multipotent self-renewing progenitor …

The regenerative process in the pancreas is of particular interest because diabetes results
from an inadequate number of insulin-producing beta cells and pancreatic cancer may arise …

The identity of niche signals necessary to maintain embryonic nephron progenitors is
unclear. Here we provide evidence that Fgf20 and Fgf9, expressed in the niche, and Fgf9 …

Acute kidney injury (AKI) is associated with prolonged hospitalization and high mortality, and
it predisposes individuals to chronic kidney disease. To date, no effective AKI treatments …

Loss of kidney function underlies many renal diseases. Mammals can partly repair their
nephrons (the functional units of the kidney), but cannot form new ones,. By contrast, fish …

Roles for monocyte/macrophages (Mφ) in directing the development of tissue fibrosis are
increasingly recognized. Macrophages form a heterogeneous group of inflammatory …

The mechanism and magnitude by which the mammalian kidney generates and maintains
its proximal tubules, distal tubules, and collecting ducts remain controversial. Here, we use …