The kidney is a model developmental system for understanding mesodermal patterning and
organogenesis, a process that requires regional specification along multiple body axes, the …

Roles for monocyte/macrophages (Mφ) in directing the development of tissue fibrosis are
increasingly recognized. Macrophages form a heterogeneous group of inflammatory …

For several decades, acute kidney injury (AKI) was generally considered a reversible
process leading to complete kidney recovery if the individual survived the acute illness …

Growing evidence suggests that transcriptional regulators and secreted RNA molecules
encapsulated within membrane vesicles modify the phenotype of target cells. Membrane …

The paracrine theory has recently changed the view of the biological action of stem cells and
of the subsequent potential application of stem cells in regenerative medicine. Indeed, most …

The mechanism and magnitude by which the mammalian kidney generates and maintains
its proximal tubules, distal tubules, and collecting ducts remain controversial. Here, we use …

Transplantation of bone marrow mesenchymal stem cells (BM-MSC) or stromal cells from
rodents has been identified as a strategy for renal repair in experimental models of acute …

Renal fibrosis is a final stage of many forms of kidney disease and leads to impairment of
kidney function. The molecular pathogenesis of renal fibrosis is currently not well …

Summary FGF, BMP, and WNT balance embryonic nephron progenitor cell (NPC) renewal
and differentiation. By modulating these pathways, we have created an in vitro niche in …

Acute kidney injury (AKI) remains a major clinical event with rising incidence, severity, and
cost; it now has a morbidity and mortality exceeding acute myocardial infarction. There is …