Tau PET imaging in neurodegenerative tauopathies—still a challenge
The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers
The diagnosis of Alzheimer's disease can be improved by the use of biological measures.
Biomarkers of functional impairment, neuronal loss, and protein deposition that can be …
Biomarkers of functional impairment, neuronal loss, and protein deposition that can be …
Tau PET imaging: present and future directions
Abnormal aggregation of tau in the brain is a major contributing factor in various
neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of …
neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of …
Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains
ML Malarte, PG Gillberg, A Kumar, N Bogdanovic… - Molecular …, 2023 - nature.com
Recent mechanistic and structural studies have challenged the classical tauopathy
classification approach and revealed the complexity and heterogeneity of tau pathology in …
classification approach and revealed the complexity and heterogeneity of tau pathology in …
In vivo characterization and quantification of neurofibrillary tau PET radioligand 18F-MK-6240 in humans from Alzheimer disease dementia to young controls
Tau PET imaging has potential for elucidating changes in the deposition of
neuropathological tau aggregates that are occurring during the progression of Alzheimer …
neuropathological tau aggregates that are occurring during the progression of Alzheimer …
Preclinical characterization of 18F-MK-6240, a promising PET tracer for in vivo quantification of human neurofibrillary tangles
ED Hostetler, AM Walji, Z Zeng, P Miller… - Journal of nuclear …, 2016 - Soc Nuclear Med
A PET tracer is desired to help guide the discovery and development of disease-modifying
therapeutics for neurodegenerative diseases characterized by neurofibrillary tangles (NFTs) …
therapeutics for neurodegenerative diseases characterized by neurofibrillary tangles (NFTs) …
SPECT and PET imaging in Alzheimer's disease
V Valotassiou, J Malamitsi, J Papatriantafyllou… - Annals of nuclear …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia. Beta-amyloid (Aβ) deposition and neurofibrillary tangles (NFTs) …
common cause of dementia. Beta-amyloid (Aβ) deposition and neurofibrillary tangles (NFTs) …
[HTML][HTML] Biomarkers for the early detection and progression of Alzheimer's disease
The recent failures of potential disease-modifying drugs for Alzheimer's disease (AD) may
reflect the fact that the enrolled participants in clinical trials are already too advanced to …
reflect the fact that the enrolled participants in clinical trials are already too advanced to …
A closer look at amyloid ligands, and what they tell us about protein aggregates
TS Chisholm, CA Hunter - Chemical Society Reviews, 2024 - pubs.rsc.org
The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …
In vivo tau PET imaging in dementia: pathophysiology, radiotracer quantification, and a systematic review of clinical findings
In addition to the deposition of β-amyloid plaques, neurofibrillary tangles composed of
aggregated hyperphosphorylated tau are one of the pathological hallmarks of Alzheimer's …
aggregated hyperphosphorylated tau are one of the pathological hallmarks of Alzheimer's …