Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand gated ion
channels which are widely distributed in the human brain. Multiple subtypes of these …

The cholinergic hypothesis claims that the decline in cognitive functions in dementia is
predominantly related to a decrease in cholinergic neurotransmission. This hypothesis has …

Most people who are regular consumers of psychoactive drugs are not drug addicts, nor will
they ever become addicts. In neurobiological theories, non-addictive drug consumption is …

Rationale Nicotine has been shown in a variety of studies in humans and experimental
animals to improve cognitive function. Nicotinic treatments are being developed as …

Objective Endophenotype studies of obsessive-compulsive disorder (OCD) may uncover
heritable traits that are related to genetic susceptibility to OCD. Deficient response inhibition …

Nicotine and other nicotinic agonists have been found to improve performance on attention
and memory tasks. Clinical studies using nicotine skin patches have demonstrated the …

Nicotinic cholinergic systems are involved with several important aspects of cognitive
function including attention, learning and memory. Nicotinic cholinergic receptors are …

Molecular cloning has elucidated the sequence of a family of acetylcholine receptor subunits
that are activated by nicotine. Subsequent studies on the localization of individual subunits …

Until recently, research on (S)-(-)-nicotine (1, hereafter simply nicotine) and nicotinic
acetylcholine receptors (nAChRs) emphasized two principal aspects. The first was the …

A promising drug target currently under investigation to improve cognitive deficits in
neuropsychiatric and neurological disorders is the neuronal nicotinic alpha7 acetylcholine …