The liver is an organ that performs a multitude of functions, and its health is pertinent and
indispensable to survival. Thus, the cellular and molecular machinery driving hepatic …

Activation of hepatic stellate cells (HSCs) is a pivotal cellular event in liver fibrosis.
Therefore, improving our understanding of the molecular pathways that are involved in these …

Background Keloid scarring is a fibroproliferative disease caused by aberrant genetic
activation with an unclear underlying mechanism. Genetic predisposition, aberrant cellular …

WNT-5A is a secreted growth factor that belongs to the noncanonical members of the
Wingless-related MMTV-integration family. Previous studies pointed to a connection …

Corneal endothelial disorders collectively represent a significant healthcare burden in most
developed nations, and corneal transplantation is currently the only treatment available for …

Objectives: Our goal was to investigate the relationship between keloid and telomerase as
well as clarifying the influence of Wnt/β-catenin signaling on keloid cell proliferation …

Aims Endotoxemia and its pro-fibrogenic signaling play a significant role in the development
of hepatic fibrosis. This study investigated whether lipopolysaccharide (LPS) directly activate …

Pygo2 has been discovered as an important Wnt signaling component contributing to the
activation of Wnt-target gene transcription. In the present study, we discovered that Pygo2 …

Hepatic stellate cells (HSCs) were recently identified as liver-resident mesenchymal stem
cells. HSCs are activated after liver injury and involved in pivotal processes, such as liver …

Abstract Background Non-canonical Wnt pathways play important roles in liver fibrosis.
Notum is a newly discovered inhibitor to Wnt proteins. This study was to investigate anti …