Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …

Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …

Background Previous studies have confirmed the oncogenic role of HMGB2 in various
cancers, but the biological functions of HMGB2-derived circRNAs remain unknown. Thus …

Glioblastoma multiforme (GBM), as a deadly and almost incurable brain cancer, is the most
invasive form of CNS tumors that affects both children and adult population. It accounts for …

Atherosclerosis is a chronic inflammatory vascular disease, and inflammation plays a critical
role in its formation and progression. Elevated serum homocysteine (Hcy) is an independent …

Non-coding RNAs (ncRNAs) regulate cell proliferation, migration, differentiation,
inflammation, metabolism of clinically important biomolecules, and other cellular processes …

Cardiovascular disease (CVD) remains the leading cause of mortality globally. Circular
RNAs (circRNAs) have attracted extensive attention for their roles in the physiological and …

Over the last four decades, methodological innovations have continuously changed
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …

Atherosclerosis is a fatal disorder that is fundamental to various cardiovascular diseases
and severely threatens people's health worldwide. Several studies have demonstrated the …

Coronary heart disease (CHD) is a prevalent global cause of death. Research suggests that
circular RNAs (circRNAs) play a role in the development of CHD. In this study, we …