3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression
V Boreikaitė, LA Passmore - Annual review of biochemistry, 2023 - annualreviews.org
Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …
transcript. This process is mediated by a number of protein factors that cleave the pre …
A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing
S Yu, VN Kim - Nature Reviews Molecular Cell Biology, 2020 - nature.com
RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …
frequent and conserved type of RNA modification. The addition of tails and their composition …
Architecture of the cytoplasmic face of the nuclear pore
INTRODUCTION Cytoplasmic face of the human NPC. Near-atomic composite structure of
the NPC generated by docking high-resolution crystal structures into a cryo‑ET …
the NPC generated by docking high-resolution crystal structures into a cryo‑ET …
Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs
L Chen, Y Wang, J Lin, Z Song, Q Wang… - Nature …, 2022 - nature.com
Numerous RNAs are exported from the nucleus, abnormalities of which lead to cellular
complications and diseases. How thousands of circular RNAs (circRNAs) are exported from …
complications and diseases. How thousands of circular RNAs (circRNAs) are exported from …
Structure and function of the nuclear pore complex
The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …
Structure of the human core transcription-export complex reveals a hub for multivalent interactions
T Pühringer, U Hohmann, L Fin, B Pacheco-Fiallos… - Elife, 2020 - elifesciences.org
The export of mRNA from nucleus to cytoplasm requires the conserved and essential
transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX …
transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX …
Nucleocytoplasmic transport defects in neurodegeneration—Cause or consequence?
S Hutten, D Dormann - Seminars in cell & developmental biology, 2020 - Elsevier
Defects in nucleocytoplasmic transport have been associated with several
neurodegenerative disorders and, in particular, the formation of pathological protein …
neurodegenerative disorders and, in particular, the formation of pathological protein …
Facioscapulohumeral muscular dystrophy: genetics, gene activation and downstream signalling with regard to recent therapeutic approaches: an update
T Schätzl, L Kaiser, HP Deigner - Orphanet Journal of Rare Diseases, 2021 - Springer
Whilst a disease-modifying treatment for Facioscapulohumeral muscular dystrophy (FSHD)
does not exist currently, recent advances in complex molecular pathophysiology studies of …
does not exist currently, recent advances in complex molecular pathophysiology studies of …
The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation
Abstract The PIWI-interacting RNA (piRNA) pathway protects genome integrity in part
through establishing repressive heterochromatin at transposon loci. Silencing requires …
through establishing repressive heterochromatin at transposon loci. Silencing requires …