The ribbon is the structural hallmark of cochlear inner hair cell (IHC) afferent synapses, yet
its role in information transfer to spiral ganglion neurons (SGNs) remains unclear. We …

Review of Hair Cell Synapse Defects in Sensorineural Hearing... : Otology & Neurotology
Review of Hair Cell Synapse Defects in Sensorineural Hearing Impairment : Otology & …

Ca2+ influx triggers the release of synaptic vesicles at the presynaptic active zone (AZ). A
quantitative characterization of presynaptic Ca2+ signaling is critical for understanding …

Regulated neurotransmitter release from presynaptic boutons is crucial for the functioning of
chemical synapses, what in turn governs the functional performance of the nervous system …

Neurons communicate through Ca2+-dependent neurotransmitter release at presynaptic
active zones (AZs). Neurotransmitter release properties play a key role in defining …

All acoustic information from the periphery is encoded in the timing and rates of spikes in the
population of spiral ganglion neurons projecting to the central auditory system …

EF-hand Ca2+-binding proteins are thought to shape the spatiotemporal properties of
cellular Ca2+ signaling and are prominently expressed in sensory hair cells in the ear. Here …

Ribbon‐class synapses in the ear achieve analog to digital transformation of a continuously
graded membrane potential to all‐or‐none spikes. In mammals, several auditory nerve …

In vision, balance and hearing, sensory receptor cells translate sensory stimuli into electrical
signals whose amplitude is graded with stimulus intensity. The output synapses of these …

Mechanisms regulating the turnover of synaptic vesicle (SV) proteins are not well
understood. They are thought to require poly-ubiquitination and degradation through …