The first synapses transmitting visual information contain an unusual organelle, the ribbon,
which is involved in the transport and priming of vesicles to be released at the active zone …

Epigenetic processes have been implicated in the pathophysiology of alcohol dependence,
but the specific molecular mechanisms mediating dependence-induced neuroadaptations …

Active zones at chemical synapses are highly specialized sites for the regulated release of
neurotransmitters. Despite a high degree of active zone protein conservation in vertebrates …

Ca2+-binding protein 2 (CaBP2) inhibits the inactivation of heterologously expressed
voltage-gated Ca2+ channels of type 1.3 (CaV1. 3) and is defective in human autosomal …

Several studies have shown the importance of calcium channels in the development and/or
maturation of synapses. The CaV1. 4 (α1F) knockout mouse is a unique model to study the …

Age‐related hearing loss (ARHL) is the most common sensory disability associated with
human aging. Yet, there are no approved measures for preventing or treating this …

Piccolo is the largest known cytomatrix protein at active zones of chemical synapses. A
growing number of studies on conventional chemical synapses assign Piccolo a role in the …

Presynaptic active zones are essential structures for synaptic vesicle release, but the
developmental regulation of their number and maintenance during aging at mammalian …

In sensory hair cells of auditory and vestibular organs, the ribbon synapse is required for the
precise encoding of a wide range of complex stimuli. Hair cells have a unique presynaptic …

Rapid information processing in our nervous system relies on high-frequency fusion of
transmitter-filled vesicles at chemical synapses. Some sensory synapses possess prominent …