Chemical carcinogenesis follows a multistep process involving both mutation and increased
cell proliferation. Oxidative stress can occur through overproduction of reactive oxygen and …

One lens with which to understand the complex phenomenon of cancer is that of
developmental biology. Cancer is the inevitable consequence of a breakdown of the …

Gap junction intercellular communication (GJIC) or cell coupling has an important function in
maintaining tissue homeostasis and is thus a critical factor in the life and death balance of …

Invariant left–right asymmetry of the visceral organs is a fundamental feature of vertebrate
embryogenesis. While a cascade of asymmetrically expressed genes has been described …

Planaria possess remarkable powers of regeneration. After bisection, one blastema
regenerates a head, while the other forms a tail. The ability of previously-adjacent cells to …

Chemically induced cancer is a multi-step process involving damage to the genome initially
followed by clonal expansion of the DNA damaged cell eventually leading to a neoplasm …

In epidermis, it has been suggested, intercellular communication through gap junctions is
important in coordinating cell behavior. The connexins, may facilitate selective assembly or …

Gap junctions permit the direct passage of small molecules from the cytosol of one cell to
that of its neighbor, and thus form a system of cell–cell communication that exists alongside …

Mesenchymal stem cells are regarded as common cellular precursors of the
musculoskeletal tissue and are responsible for tissue regeneration in the course of …

There is a large body of evidence suggesting the connexin gap junction proteins appear to
act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main …