The retina is an exquisite target for defects of oxidative phosphorylation (OXPHOS)
associated with mitochondrial impairment. Retinal involvement occurs in two ways, retinal …

Options for the effective treatment of hereditary optic neuropathies have been a long time
coming. The successful launch of the antioxidant idebenone for Leber's Hereditary Optic …

We previously established the contribution of de novo damaging sequence variants to
Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence …

Melatonin is a pleiotropic, indole secreted, and synthesized by the human pineal gland.
Melatonin has biological effects including anti-apoptosis, protecting mitochondria, anti …

Significance: In addition to their classical role in cellular ATP production, mitochondria are of
key relevance in various (patho) physiological mechanisms including second messenger …

Hereditary optic neuropathies result from defects in the human genome, both nuclear and
mitochondrial. The two main and most recognised phenotypes are dominant optic atrophy …

The metabolic patterns and energetics of human induced pluripotent stem cell-derived
cardiomyocytes (HiPSC-CMs) are much less than those of normal adult cardiomyocytes …

Recombinant adeno-associated virus (AAV) vectors are one of the main gene delivery
vehicles used in retinal gene therapy approaches; however, there is a need to further …

Mitochondrial dynamics homeostasis is sustained by continuous and balanced fission and
fusion, which are determinants of morphology, abundance, biogenesis and mitophagy of …

The most prevalent dementia-causing neurodegenerative condition is Alzheimer's disease
(AD). The aberrant buildup of amyloid β and tau hyperphosphorylation are the two most well …