Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Lysine acetylation is a conserved, reversible, post-translational protein modification
regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known …

Lysine acetylation is a major posttranslational modification involved in a broad array of
physiological functions. Here, we provide an organ-wide map of lysine acetylation sites from …

Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However,
there are a number of universal aberrations common to all cancers, one of these being the …

Research over the past three decades has firmly established lysine acetyltransferases
(KATs) as central players in regulating transcription. Recent advances in genomic …

Healthy aging depends on removal of damaged cellular material that is in part mediated by
autophagy. The nutritional status of cells affects both aging and autophagy through as-yet …

Resistance of cancer cells to chemotherapeutics and emerging targeted drugs is a
devastating problem in the treatment of cancer patients. Multiple mechanisms contribute to …