Evidence about the relative effects of new treatments is typically collected in randomised
controlled trials (RCTs). In many instances, evidence from RCTs falls short of the needs of …

Optimal growth and development in childhood and adolescence is crucial for lifelong health
and well-being,,,,–. Here we used data from 2,325 population-based studies, with …

Introduction The diagnosis of acute appendicitis remains challenging. This review
determined the current diagnostic accuracy of CT and ultrasound for suspected acute …

Importance Although numerous studies have separately investigated the associations of
changes in weight or waist circumference with mortality risk, few studies have examined the …

Comment 234 www. thelancet. com/diabetes-endocrinology Vol 10 April 2022 diseases
(simple multimorbidity), 8· 18 (7· 12–9· 39) for three diseases, and 12· 39 (9· 26–16· 58) for …

Body Mass Index (BMI) is divided into four categories according to Asian classification:
Underweight (< 18.5 kg/m 2), normal weight (18.5–22.9 kg/m 2), overweight (23–24.9 kg/m …

Traditionally regarded as a disease of older adults, in the last two decades type 2 diabetes
has increasingly been diagnosed in children, adolescents and young adults in many …

The normal incretin effect—an enhanced prandial insulin response—is mediated mostly by
meal-stimulated release of the intestinal hormones GLP-1 and glucose-dependent …

Background: A poor diet contributes substantially to the development of noncommunicable
diseases. In Singapore, it is recommended to consume at least 2 servings of fruits and …

Excessive body weight during adolescence represents a significant public health problem
worldwide. Identifying factors associated with its development is crucial. We estimated the …