Pharmacology and structure of P2Y receptors

I von Kügelgen, K Hoffmann - Neuropharmacology, 2016 - Elsevier
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y 1, P2Y 2, P2Y 4, P2Y …

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

MP Abbracchio, G Burnstock, JM Boeynaems… - Pharmacological …, 2006 - ASPET
There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

Pharmacological profiles of cloned mammalian P2Y-receptor subtypes

I von Kügelgen - Pharmacology & therapeutics, 2006 - Elsevier
Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

Pharmacology of P2Y receptors

I von Kügelgen - Brain research bulletin, 2019 - Elsevier
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …

Purinergic neuron-to-glia signaling in the enteric nervous system

BD Gulbransen, KA Sharkey - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Enteric glia are intimately associated with neurons in the enteric
nervous system (ENS) and display morphologic and molecular similarities to central nervous …

Molecular pharmacology, physiology, and structure of the P2Y receptors

I von Kügelgen, TK Harden - Advances in pharmacology, 2011 - Elsevier
The P2Y receptors are a widely expressed group of eight nucleotide-activated G protein-
coupled receptors (GPCRs). The P2Y 1 (ADP), P2Y 2 (ATP/UTP), P2Y 4 (UTP), P2Y 6 …

P2 receptors activated by uracil nucleotides-an update

A Brunschweiger, CE Muller - Current medicinal chemistry, 2006 - ingentaconnect.com
Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling
molecules which activate G protein-coupled membrane receptors (GPCRs) of the P2Y …

[HTML][HTML] SARS-CoV-2 Spike protein alters microglial purinergic signaling

VS Alves, SACS Santos, R Leite-Aguiar… - Frontiers in …, 2023 - frontiersin.org
Despite long-term sequelae of COVID-19 are emerging as a substantial public health
concern, the mechanism underlying these processes still unclear. Evidence demonstrates …

Extended pharmacological profiles of rat P2Y2 and rat P2Y4 receptors and their sensitivity to extracellular H+ and Zn2+ ions

SS Wildman, RJ Unwin, BF King - British journal of …, 2003 - Wiley Online Library
Two molecularly distinct rat P2Y receptors activated equally by adenosine‐5′‐triphosphate
(ATP) and uridine‐5′‐triphosphate (UTP)(rP2Y2 and rP2Y4 receptors) were expressed in …

P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: effects of extracellular nucleotides on apoptosis and cell proliferation

R Coutinho-Silva, L Stahl, KK Cheung… - American Journal …, 2005 - journals.physiology.org
Extracellular nucleotides interact with purinergic receptors, which regulate ion transport in a
variety of epithelia. With the use of two different human epithelial carcinoma cell lines (HCT8 …