[HTML][HTML] SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies
Monoclonal antibodies (mAbs) offer a treatment option for individuals with severe COVID-19
and are especially important in high-risk individuals where vaccination is not an option …
and are especially important in high-risk individuals where vaccination is not an option …
[HTML][HTML] Principles of SARS-CoV-2 glycosylation
The structure and post-translational processing of the SARS-CoV-2 spike glycoprotein (S) is
intimately associated with the function of the virus and of sterilising vaccines. The surface of …
intimately associated with the function of the virus and of sterilising vaccines. The surface of …
Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain
KG Nabel, SA Clark, S Shankar, J Pan, LE Clark… - Science, 2021 - science.org
Many studies have examined the impact of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variants on neutralizing antibody activity after they have become dominant …
(SARS-CoV-2) variants on neutralizing antibody activity after they have become dominant …
Selection analysis identifies clusters of unusual mutational changes in Omicron lineage BA. 1 that likely impact Spike function
Among the 30 nonsynonymous nucleotide substitutions in the Omicron S-gene are 13 that
have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within …
have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within …
Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses
X Ou, G Xu, P Li, Y Liu, F Zan, P Liu, J Hu, X Lu… - Cell discovery, 2023 - nature.com
The bat coronaviruses (CoV) BANAL-20-52 and BANAL-20-236 are two newly identified
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) closely related …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) closely related …
A defective viral genome strategy elicits broad protective immunity against respiratory viruses
RNA viruses generate defective viral genomes (DVGs) that can interfere with replication of
the parental wild-type virus. To examine their therapeutic potential, we created a DVG by …
the parental wild-type virus. To examine their therapeutic potential, we created a DVG by …
Predicting antiviral resistance mutations in SARS-CoV-2 main protease with computational and experimental screening
The main protease (Mpro) of SARS-CoV-2 is essential for viral replication and has been the
focus of many drug discovery efforts since the start of the COVID-19 pandemic. Nirmatrelvir …
focus of many drug discovery efforts since the start of the COVID-19 pandemic. Nirmatrelvir …
SARS-CoV-2-specific T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals
J Lang-Meli, H Luxenburger, K Wild, V Karl… - Nature …, 2022 - nature.com
Continuously emerging variants of concern (VOCs) sustain the SARS-CoV-2 pandemic. The
SARS-CoV-2 Omicron/B. 1.1. 529 VOC harbours multiple mutations in the spike protein …
SARS-CoV-2 Omicron/B. 1.1. 529 VOC harbours multiple mutations in the spike protein …
Effect of polymorphism in Rhinolophus affinis ACE2 on entry of SARS-CoV-2 related bat coronaviruses
P Li, J Hu, Y Liu, X Ou, Z Mu, X Lu, F Zan, M Cao… - PLoS …, 2023 - journals.plos.org
Bat coronavirus RaTG13 shares about 96.2% nucleotide sequence identity with that of
SARS-CoV-2 and uses human and Rhinolophus affinis (Ra) angiotensin-converting enzyme …
SARS-CoV-2 and uses human and Rhinolophus affinis (Ra) angiotensin-converting enzyme …
[HTML][HTML] Molecular insights into the adaptive evolution of SARS-CoV-2 spike protein
Z Yao, L Zhang, Y Duan, X Tang, J Lu - Journal of Infection, 2024 - Elsevier
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has substantially damaged the global economy and human health. The …
(SARS-CoV-2), has substantially damaged the global economy and human health. The …