The microbiome and gut homeostasis

JY Lee, RM Tsolis, AJ Bäumler - Science, 2022 - science.org
Changes in the composition of the gut microbiota are associated with many human
diseases. So far, however, we have failed to define homeostasis or dysbiosis by the …

Chronic kidney disease

K Kalantar-Zadeh, TH Jafar, D Nitsch, BL Neuen… - The lancet, 2021 - thelancet.com
Chronic kidney disease is a progressive disease with no cure and high morbidity and
mortality that occurs commonly in the general adult population, especially in people with …

Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

Gut microbiota-derived metabolites as central regulators in metabolic disorders

A Agus, K Clément, H Sokol - Gut, 2021 - gut.bmj.com
Metabolic disorders represent a growing worldwide health challenge due to their
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …

Total volatile basic nitrogen (TVB-N) and its role in meat spoilage: A review

AEDA Bekhit, BWB Holman, SG Giteru… - Trends in Food Science & …, 2021 - Elsevier
Background Meat is a perishable product and during storage, the actions of microorganisms
and endogenous enzymes result in chemical compositional changes. Total volatile basic …

Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer

R Jalandra, N Dalal, AK Yadav, D Verma… - Applied Microbiology …, 2021 - Springer
Among gut microbiota-derived metabolites, trimethylamine-N-oxide (TMAO) is receiving
increased attention due to its possible role in the carcinogenesis of colorectal cancer (CRC) …

Gut microbiota in human metabolic health and disease

Y Fan, O Pedersen - Nature Reviews Microbiology, 2021 - nature.com
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …

Microbiota succession throughout life from the cradle to the grave

C Martino, AH Dilmore, ZM Burcham… - Nature Reviews …, 2022 - nature.com
Associations between age and the human microbiota are robust and reproducible. The
microbial composition at several body sites can predict human chronological age relatively …

[PDF][PDF] The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

H Wang, X Rong, G Zhao, Y Zhou, Y Xiao, D Ma, X Jin… - Cell metabolism, 2022 - cell.com
Immunotherapy has achieved limited success in patients with triple-negative breast cancer
(TNBC), an aggressive disease with a poor prognosis. Commensal microbiota have been …