The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the …

Background and Purpose—Traditionally, cell death after cerebral ischemia was considered
to be exclusively necrotic in nature, but research over the past decade has revealed that …

The initial reports regarding a cytotoxic role of calcium ions were published over 30 years
ago. In neurons, calcium ions can gain entry into the cell through several mechanisms …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …

Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in
thedeveloping and adult mammalian brain. BDNF/TrkB-stimulated intracellular signaling is …

Transient receptor potential (TRP) channels are a large family of ion channel proteins,
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …

Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation
of the CNS, including neuronal morphology and synapse refinement. Herein, we …

Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …