The glutamate receptor was one of the most intensely investigated targets for
neuroprotection. However, numerous clinical trials of glutamate receptor antagonists for the …

TRP channels constitute a large superfamily of cation channel forming proteins, all related to
the gene product of the transient receptor potential (trp) locus in Drosophila. In mammals, 28 …

The hereditary ataxias are a complex group of neurological disorders characterized by the
degeneration of the cerebellum and its associated connections. The molecular mechanisms …

Background Patients with glioblastoma multiforme, the most aggressive form of glioma, have
a median survival of approximately 12 months. Calcium (Ca 2+) signaling plays an important …

Mutations in the canonical transient receptor potential channel TRPC6 lead to an autosomal
dominant form of human kidney disease characterized histologically by focal and segmental …

Proximal spinal muscular atrophy (SMA) is a motoneuron disease for which there is currently
no effective treatment. In animal models of SMA, spinal motoneurons exhibit reduced axon …

Cation channels of the TRP superfamily are widely expressed in the nervous system, and
important progress has been made in elucidating the gating properties and physiological …

Ischemic stroke is one of the most disabling diseases and a leading cause of death globally.
Despite advances in medical care, the global burden of stroke continues to grow, as no …

Stroke is a leading cause of human death and disability in the USA and around the world.
Shortly after the cerebral ischemia, cell swelling is the earliest morphological change in …

The canonical transient receptor potential channels (TRPCs) are Ca2+-permeable
nonselective cation channels with various physiological functions. Here, we report that …