[HTML][HTML] Brain-derived neurotrophic factor regulates TRPC3/6 channels and protects against myocardial infarction in rodents

P Hang, J Zhao, B Cai, S Tian, W Huang… - … journal of biological …, 2015 - ncbi.nlm.nih.gov
Background: Brain-derived neurotrophic factor (BDNF) is associated with coronary artery
diseases. However, its role and mechanism in myocardial infarction (MI) is not fully …

Brain-derived neurotrophic factor (BDNF)-induced mitochondrial motility arrest and presynaptic docking contribute to BDNF-enhanced synaptic transmission*♦

B Su, YS Ji, X Sun, XH Liu, ZY Chen - Journal of Biological Chemistry, 2014 - ASBMB
Appropriate mitochondrial transport and distribution are essential for neurons because of the
high energy and Ca 2+ buffering requirements at synapses. Brain-derived neurotrophic …

[HTML][HTML] TRP Channels in the Brain

S Sawamura, H Shirakawa, T Nakagawa… - Neurobiology of TRP …, 2017 - ncbi.nlm.nih.gov
Transient receptor potential (TRP) family proteins form tetrameric nonselective cation
channels. Upon activation, TRP channels depolarize the membrane potential, which can …

TRP channels: role in neurodegenerative diseases and therapeutic targets

MA Rather, A Khan, L Wang, S Jahan, MU Rehman… - Heliyon, 2023 - cell.com
TRP (Transient receptor potential) channels are integral membrane proteins consisting of a
superfamily of cation channels that allow permeability of both monovalent and divalent …

TRPC6 attenuates cortical astrocytic apoptosis and inflammation in cerebral ischemic/reperfusion injury

L Liu, M Chen, K Lin, X Xiang, J Yang… - Frontiers in Cell and …, 2021 - frontiersin.org
Transient receptor potential canonical 6 (TRPC6) channel is an important non-selective
cation channel with a variety of physiological roles in the central nervous system. Evidence …

TRPC 6 channel‐mediated neurite outgrowth in PC 12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI 3K, and CAMKIV signaling

JH Heiser, AM Schuwald, G Sillani, L Ye… - Journal of …, 2013 - Wiley Online Library
The non‐selective cationic transient receptor canonical 6 (TRPC 6) channels are involved in
synaptic plasticity changes ranging from dendritic growth, spine morphology changes and …

IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice

J Zhang, X Mao, T Zhou, X Cheng, Y Lin - Neuroscience, 2014 - Elsevier
Abstract Interleukin (IL)-17A plays an important role in the cerebral ischemia/reperfusion
(I/R) injury. However, the mechanisms are still largely unknown. Calpain-transient receptor …

HIV-1 Tat-mediated calcium dysregulation and neuronal dysfunction in vulnerable brain regions

XT Hu - Current drug targets, 2016 - ingentaconnect.com
Despite the success of combined antiretroviral therapy, more than half of HIV-1-infected
patients in the USA show HIV-associated neurological and neuropsychiatric deficits. This is …

Cell death by necrosis, a regulated way to go

M Henriquez, R Armisen, A Stutzin… - Current molecular …, 2008 - ingentaconnect.com
Apoptosis is a programmed form of cell death with well-defined morphological traits that are
often associated with activation of caspases. More recently evidence has become available …

Role of TRPM2 in H2O2-Induced Cell Apoptosis in Endothelial Cells

L Sun, HY Yau, WY Wong, RA Li, Y Huang, X Yao - 2012 - journals.plos.org
Melastatin-like transient receptor potential channel 2 (TRPM2) is an oxidant-sensitive and
cationic non-selective channel that is expressed in mammalian vascular endothelium. Here …