Regulation of inflammation by the antioxidant haem oxygenase 1
NK Campbell, HK Fitzgerald, A Dunne - Nature Reviews Immunology, 2021 - nature.com
Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …
haem, is primarily considered an antioxidant, and has long been overlooked by …
Heme oxygenase-1: an anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders
SW Ryter - Antioxidants, 2022 - mdpi.com
The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
A Loboda, M Damulewicz, E Pyza, A Jozkowicz… - Cellular and molecular …, 2016 - Springer
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not
only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant …
only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant …
Heme oxygenase-1 signaling and redox homeostasis in physiopathological conditions
V Consoli, V Sorrenti, S Grosso, L Vanella - Biomolecules, 2021 - mdpi.com
Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …
Oxidant mechanisms in renal injury and disease
BB Ratliff, W Abdulmahdi, R Pawar… - Antioxidants & redox …, 2016 - liebertpub.com
Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …
Heme oxgenase-1, a cardinal modulator of regulated cell death and inflammation
SW Ryter - Cells, 2021 - mdpi.com
Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …
The therapeutic potential of carbon monoxide
R Motterlini, LE Otterbein - Nature reviews Drug discovery, 2010 - nature.com
Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic
molecule with important signalling capabilities in physiological and pathophysiological …
molecule with important signalling capabilities in physiological and pathophysiological …
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
SW Ryter, AMK Choi - Translational Research, 2016 - Elsevier
The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …
[HTML][HTML] Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases
SC Funes, M Rios, A Fernández-Fierro… - Frontiers in …, 2020 - frontiersin.org
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group
degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which …
degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which …
Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS
F Momen-Heravi, S Bala, K Kodys, G Szabo - Scientific reports, 2015 - nature.com
Hepatocyte damage and inflammation in monocytes/macrophages are central to the
pathogenesis of alcoholic hepatitis (AH). MicroRNAs (miRNAs) regulate all of these …
pathogenesis of alcoholic hepatitis (AH). MicroRNAs (miRNAs) regulate all of these …