Transmembrane TNF-α: structure, function and interaction with anti-TNF agents
T Horiuchi, H Mitoma, S Harashima… - …, 2010 - academic.oup.com
Transmembrane TNF-α, a precursor of the soluble form of TNF-α, is expressed on activated
macrophages and lymphocytes as well as other cell types. After processing by TNF-α …
macrophages and lymphocytes as well as other cell types. After processing by TNF-α …
Cell death mechanisms induced by cytotoxic lymphocytes
L Chavez-Galan, AD Angel, E Zenteno… - Cellular & molecular …, 2009 - nature.com
One of the functions of the immune system is to recognize and destroy abnormal or infected
cells to maintain homeostasis. This is accomplished by cytotoxic lymphocytes. Cytotoxicity is …
cells to maintain homeostasis. This is accomplished by cytotoxic lymphocytes. Cytotoxicity is …
[HTML][HTML] Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy
CA Klebanoff, CD Scott, AJ Leonardi… - The Journal of …, 2016 - Am Soc Clin Investig
Adoptive cell transfer (ACT) of purified naive, stem cell memory, and central memory T cell
subsets results in superior persistence and antitumor immunity compared with ACT of …
subsets results in superior persistence and antitumor immunity compared with ACT of …
[HTML][HTML] The CD95 receptor: apoptosis revisited
ME Peter, RC Budd, J Desbarats, SM Hedrick… - Cell, 2007 - cell.com
The CD95 Receptor: Apoptosis Revisited: Cell Skip to Main Content Advertisement Cell This
journal offers authors two options (open access or subscription) to publish research Submit Log …
journal offers authors two options (open access or subscription) to publish research Submit Log …
[HTML][HTML] ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death
M Schulte, K Reiss, M Lettau, T Maretzky… - Cell Death & …, 2007 - nature.com
The apoptosis-inducing Fas ligand (FasL) is a type II transmembrane protein that is involved
in the downregulation of immune reactions by activation-induced cell death (AICD) as well …
in the downregulation of immune reactions by activation-induced cell death (AICD) as well …
A new class of reverse signaling costimulators belongs to the TNF family
M Sun, PJ Fink - The Journal of Immunology, 2007 - journals.aai.org
Recent evidence shows that many molecules of the TNF family serve as counter-receptors,
inducing costimulation through reverse signals in addition to delivering signals through their …
inducing costimulation through reverse signals in addition to delivering signals through their …
[HTML][HTML] The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells
V Kirkin, N Cahuzac, F Guardiola-Serrano… - Cell Death & …, 2007 - nature.com
Fas ligand (FasL) is a type II transmembrane protein belonging to the tumor necrosis factor
family. Its binding to the cognate Fas receptor triggers the apoptosis that plays a pivotal role …
family. Its binding to the cognate Fas receptor triggers the apoptosis that plays a pivotal role …
Importance of reverse signaling of the TNF superfamily in immune regulation
K Juhasz, K Buzas, E Duda - Expert review of clinical immunology, 2013 - Taylor & Francis
TNF-related ligands (with the exception of lymphotoxin-α) are synthesized as type II
transmembrane proteins, though many of them also have soluble forms. An increasing …
transmembrane proteins, though many of them also have soluble forms. An increasing …
[HTML][HTML] Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases
V Risso, E Lafont, M Le Gallo - Cell death & disease, 2022 - nature.com
Cell death plays a pivotal role in the maintenance of tissue homeostasis. Key players in the
controlled induction of cell death are the Death Receptors (DR). CD95 is a prototypic DR …
controlled induction of cell death are the Death Receptors (DR). CD95 is a prototypic DR …
[HTML][HTML] Pro-and anti-apoptotic CD95 signaling in T cells
M Paulsen, O Janssen - Cell Communication and Signaling, 2011 - Springer
The TNF receptor superfamily member CD95 (Fas, APO-1, TNFRSF6) is known as the
prototypic death receptor in and outside the immune system. In fact, many mechanisms …
prototypic death receptor in and outside the immune system. In fact, many mechanisms …