Energy availability (EA) is defined as the amount of dietary energy available to sustain
physiological function after subtracting the energetic cost of exercise. Insufficient EA due to …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

Because leptin reduces food intake and body weight, the coexistence of elevated leptin
levels with obesity is widely interpreted as evidence of 'leptin resistance.'Indeed, obesity …

Obesity plays a causative role in the pathogenesis of the metabolic syndrome. Adipokines
may link obesity to its co-morbidities. Most adipokines with pro-inflammatory properties are …

Body fat distribution is an important metabolic and cardiovascular risk factor, because the
proportion of abdominal to gluteofemoral body fat correlates with obesity-associated …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Obesity develops when energy intake exceeds energy expenditure. Although most current
obesity therapies are focused on reducing calorific intake, recent data suggest that …

Obesity, the most common nutritional disorder in industrialized countries, is associated with
an increased mortality and morbidity of cardiovascular disease (CVD). Obesity is primarily …

Leptin was initially best known for its role in energy homeostasis and regulation of energy
expenditure. In the past few years we have realized that leptin also plays a major role in …