Epigenetic dysregulation has long been recognized as a key factor contributing to
tumorigenesis and tumour maintenance that can influence all of the recognized hallmarks of …

Valproic acid (VPA), a branched short‐chain fatty acid, is widely used as an antiepileptic
drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of …

Among many anticancer drugs collectively named “targeted or molecular therapies”
epigenetic drugs are clearly promising. Differently from other agents targeting a single gene …

Recently, despite the great success achieved by the so‐called “magic bullets” in the
treatment of different diseases through a marked and specific interaction with the target of …

Drug repositioning has gained attention from both academia and pharmaceutical companies
as an auxiliary process to conventional drug discovery. Chemotherapeutic agents have …

Histones are a family of nuclear proteins that interact with DNA, resulting in DNA being
wrapped around a core of histone octamer within the nucleosome. Acetylation/deacetylation …

Background Histone deacetylase inhibitors (HDACis) re-express silenced tumor suppressor
genes and are currently undergoing clinical trials. Although HDACis have been known to …

Valproic acid (2-propyl pentanoic acid) is a drug used for the treatment of epilepsy and
bipolar disorder. Although very rare, side effects such as spina bifida and other defects of …

Overexpression of interleukin 6 (IL-6) has been proposed to contribute to pulmonary fibrosis
and other fibrotic diseases. However, the regulatory mechanisms and the role of IL-6 in …

During cancer development and progression, tumor cells undergo abnormal epigenetic
modifications, including DNA methylation, histone deacetylation and nucleosome …