Physiological Approach to Assessment of Acid–Base Disturbances | NEJM Skip to main content
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Context. Methanol, ethylene glycol, diethylene glycol, and propylene glycol intoxications are
associated with cellular dysfunction and an increased risk of death. Adverse effects can …

Methanol intoxication is an uncommon but serious poisoning. Its adverse effects are due
primarily to the impact of its major metabolite formic acid and lactic acid resulting from …

Ethylene glycol poisoning, while uncommon, is clinically significant due to the associated
risk of severe morbidity or lethality and it continues to occur in many countries around the …

An increase in serum osmolality and serum osmolal gap with or without high-anion-gap
metabolic acidosis is an important clue to exposure to one of the toxic alcohols, which …

Background: Although serum osmolal gap can be a useful diagnostic tool, clinicians are not
familiar with its use in clinical practice. Objectives: The review presents in a series of …

Background Osmolality reflects the concentration of all dissolved particles in a body fluid,
and its measurement is routinely performed in clinical laboratories for the differential …

Abstract Background Sodium-glucose cotransporter-2 (SGLT2) inhibitor medications are a
class of antihyperglycemic agents that increase urinary glucose excretion by interfering with …

Alcoholic patients commonly develop a variety of acid-base and electrolyte disturbances.
The aim of this review is to describe the most commonly encountered abnormalities and …

Acid–base homeostasis is fundamental for life. The body is exceptionally sensitive to
changes in pH, and as a result, potent mechanisms exist to regulate the body's acid–base …