Mitotic catastrophe is distinct from other cell death modes due to unique nuclear alterations
characterized as multi and/or micronucleation. Mitotic catastrophe is a common and virtually …

Abstract RhoJ is a Rho GTPase that belongs to the Cdc42 subfamily and has a molecular
weight of approximately 21 kDa. It can activate the p21-activated kinase family either directly …

Background and objectives: Non-small cell lung cancer (NSCLC) is often caused by EGFR
mutations, leading to overactive cell growth pathways. Drug resistance is a significant …

High blood sugar and insulin insensitivity causes the lifelong chronic metabolic disease
called Type 2 diabetes (T2D) which has a higher chance of developing different …

Novel tissue-agnostic therapeutics targeting driver mutations in tumor cells have been
recently approved by FDA, driven by basket trials that have demonstrated their efficacy and …

Among the tumor suppressor genes, TP53 is the most frequently mutated in human cancers,
and most mutations are missense mutations causing production of mutant p53 (mutp53) …

Background Toxic components frequently exhibit unique characteristics and activities,
offering ample opportunities for the advancement of anti-cancer medications. As the main …

Over the past few years, there has been a gradual increase in the incidence of cancer,
affecting individuals at younger ages. With its refractory nature and substantial fatality rate …

Exposure to particulate matter is associated with DNA damage and the risk of lung cancer.
Protein p53 is activated by multi-site phosphorylation in the early stages of DNA damage …

由TP53 编码的P53 蛋白是防止细胞癌变所需的关键因子, 有广泛而强大的功能. P53
在诱导细胞周期停滞, DNA 损伤修复, 细胞凋亡和衰老等过程中发挥重要作用 …