Pharmacology and therapeutics of bronchodilators revisited

MG Matera, CP Page, L Calzetta, P Rogliani… - Pharmacological …, 2020 - ASPET
Bronchodilators remain the cornerstone of the treatment of airway disorders such as asthma
and chronic obstructive pulmonary disease (COPD). There is therefore considerable interest …

The impact of chronic bronchial infection in COPD: a proposal for management

MA Martinez-Garcia, M Miravitlles - International journal of chronic …, 2022 - Taylor & Francis
Up to 50% of patients with chronic obstructive pulmonary disease (COPD) in stable state
may carry potentially pathogenic microorganisms (PPMs) in their airways. The presence of …

Bronchial epithelial cell extracellular vesicles ameliorate epithelial–mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization

S He, D Chen, M Hu, L Zhang, C Liu, D Traini… - … , Biology and Medicine, 2019 - Elsevier
Chronic obstructive pulmonary disease (COPD) is partly characterized as epithelial–
mesenchymal transition (EMT)-related airflow limitation. Extracellular vesicles (EVs) play …

Stepwise management of COPD: What is next after bronchodilation?

M Miravitlles, K Matsunaga… - Therapeutic advances in …, 2023 - journals.sagepub.com
Inhaled bronchodilator therapy with long-acting muscarinic antagonists (LAMAs) and long-
acting β2-agonists (LABAs) in combination is currently the mainstay of treatment for chronic …

Practical guide to the identification and diagnosis of asthma-COPD overlap (ACO)

A Nuñez, M Sarasate, E Loeb, C Esquinas… - COPD: Journal of …, 2019 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality
around the world. COPD is characterised by a heterogeneous clinical presentation and …

[HTML][HTML] Exercise capacity and physical activity in COPD patients treated with a LAMA/LABA combination: a systematic review and meta-analysis

M Miravitlles, JL García-Rivero, X Ribera, J Galera… - Respiratory …, 2022 - Springer
Background Persistent airflow limitation and dyspnoea may reduce chronic obstructive
pulmonary disease (COPD) patients exercise capacity and physical activity, undermining …

[HTML][HTML] Screening and diagnosis of chronic pharyngitis based on deep learning

Z Li, J Huang, Z Hu - … Journal of Environmental Research and Public …, 2019 - mdpi.com
Chronic pharyngitis is a common disease, which has a long duration and a wide range of
onset. It is easy to misdiagnose by mistaking it with other diseases, such as chronic …

[HTML][HTML] COPD overdiagnosis in primary care: a UK observational study of consistency of airflow obstruction

L Josephs, D Culliford, M Johnson… - NPJ primary care …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is heterogeneous, but persistent airflow
obstruction (AFO) is fundamental to diagnosis. We studied AFO consistency from initial …

[HTML][HTML] Triple inhaled therapy in COPD patients: determinants of prescription in primary care

DL Vetrano, A Zucchelli, E Bianchini, C Cricelli… - Respiratory …, 2019 - Elsevier
Objective To assess the incidence and determinants of the triple inhaled therapy in chronic
obstructive pulmonary disease (COPD) primary care patients. Methods Data derived from …

[PDF][PDF] Controversies and limitations in the diagnosis of chronic obstructive pulmonary disease

A Reyes-García, L Torre-Bouscoulet… - … de investigación clínica, 2019 - scielo.org.mx
Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and
mortality worldwide. While the cut-off point to define airflow obstruction has been …