Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
Microglia regulation of central nervous system myelin health and regeneration
SA Kent, VE Miron - Nature Reviews Immunology, 2024 - nature.com
Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …
its development, homeostasis and response to damage and infection. Although microglia …
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy
Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …
CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging
A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present …
underlying mechanisms leading to white matter pathology are unknown. In the present …
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models
Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …
[HTML][HTML] Disease-associated oligodendrocyte responses across neurodegenerative diseases
S Pandey, K Shen, SH Lee, YAA Shen, Y Wang… - Cell reports, 2022 - cell.com
Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative
diseases, so understanding oligodendrocyte activation states would shed light on disease …
diseases, so understanding oligodendrocyte activation states would shed light on disease …
Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination
Demyelination is a hallmark of multiple sclerosis, leukoencephalopathies, cerebral
vasculopathies, and several neurodegenerative diseases. The cuprizone mouse model is …
vasculopathies, and several neurodegenerative diseases. The cuprizone mouse model is …
Molecular and metabolic heterogeneity of astrocytes and microglia
Astrocytes and microglia are central players in a myriad of processes in the healthy and
diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell …
diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell …
Revisiting the neuroinflammation hypothesis in Alzheimer's disease: A focus on the druggability of current targets
M Wong-Guerra, C Calfio, RB Maccioni… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common form of neurodegenerative disease and
disability in the elderly; it is estimated to account for 60%–70% of all cases of dementia …
disability in the elderly; it is estimated to account for 60%–70% of all cases of dementia …
Reactive astrogliosis in the era of single-cell transcriptomics
Reactive astrogliosis is a reaction of astrocytes to disturbed homeostasis in the central
nervous system (CNS), accompanied by changes in astrocyte numbers, morphology, and …
nervous system (CNS), accompanied by changes in astrocyte numbers, morphology, and …